Towards valid brain iron quantification using magnetic resonance imaging: development of a histologically based 3D iron and myelin validation map and its comparison to quantitative susceptibility mapping

iatlasBrain iron is according to many studies related to neurodegenerative disease such as Alzheimer’s disease and Parkinson’s disease. Quantitative susceptibility mapping (QSM) and R2* mapping are promising tools to image and analyze areas of increased iron levels within the human brain by using magnetic resonance imaging (MRI). Both QSM and R2* are well established methods for isotropic deep gray matter, but the situation is more complex for white matter regions. The aim of this project is to create a 3D iron atlas and a myelin atlas of a whole human brain in order to evaluate QSM and R2* mapping. The iron atlas and the myelin map will be based on 2D histological analysis (iron and myelin staining) and the ferrozine assay will be used to calculate a quantitative iron map. In order to create a 3D map of the iron and myelin concentrations, the 2D iron and myelin stains will be reconstructed to a 3D volume referred to as atlas.


Laufzeit Juni/2015 – April/2017
FH-Projektleitung Günther Grabner
ProjektmitarbeiterInnen Max Prihoda
Forschungsschwerpunkt Diagnostik in der Medizin
Studiengang Gesundheitsberufe
Forschungsprogramm Subventionsvereinbarung im Rahmen des ÖNB-Projekts 16153
Förderinstitution/Auftraggeber Medizinische Universität Wien


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